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| Milla Jovovich | Alice / Alicia Marcus | |
| Iain Glen | Dr. Isaacs | |
| Ali Larter | Claire Redfield | |
| Shawn Roberts | Wesker | |
| Eoin Macken | Doc | |
| Fraser James | Razor | |
| Ruby Rose | Abigail | |
| William Levy | Christian | |
| Rola | Cobalt | |
| Ever Anderson | Young Alicia / Red Queen | |
| Mark Simpson | James Marcus | |
| Milton Schorr | Thin Man | |
| Siobhan Hodgson | Emaciated Woman | |
| Joon-Gi Lee | Commander Chu | |
| Aubrey Shelton | Scars | |
| Milla Jovovich | Alice | |
| Ever Anderson | Young Alicia | |
| Caroline Midgley | One Ear | |
| Dylan Skews | Commander Crunch | |
| Kevin Otto | Male Teacher | |
| Lee Raviv | School Girl | |
| Deniel Denysschen | School Boy | |
| Leo Russel | School Child | |
| Matthew Bartman | School Child | |
| Raquel Gecelter | School Child | |
| Rebecca Welmans | School Child | |
| Vian Singleton | School Child |
| Regisseur |
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| Producent |
Paul W.S. Anderson
Jeremy Bolt |
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| Schrijver |
Paul W.S. Anderson
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| Camerawerk |
Glen MacPherson
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| Muzikant |
Paul Haslinger
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Picking up immediately after the events in Resident Evil: Retribution, Alice (Milla Jovovich) is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began - The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse. |
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