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| Kevin Dorman | Chris Redfield | |
| Matthew Mercer | Leon S. Kennedy | |
| Erin Cahill | Rebecca Chambers | |
| John DeMita | Glenn Arias | |
| Fred Tatasciore | Diego Gomez | |
| Cristina Valenzuela | Maria Gomez | |
| Arif S. Kinchen | D.C. | |
| Arnie Pantoja | Damian | |
| Kari Wahlgren | Nadia | |
| Alexander Polinsky | Patricio | |
| Jason Faunt | Aaron | |
| Karen Strassman | Kathy White | |
| Mary Elizabeth McGlynn | Zack White | |
| Fryda Wolff | Patricio's Wife | |
| Jason Hightower | Captain | |
| Darin de Paul | Zombie | |
| Orion Acaba | Soldier | |
| Brian T. Delaney | Soldier | |
| Tony Oliver | Soldier | |
| David Vincent | Soldier | |
| Bridget Hoffman | Additional Voices | |
| Rif Hutton | Additional Voices | |
| Alexis Lang | Additional Voices | |
| Misty Lee | Additional Voices | |
| Akihiko Sai | Diego Gomez |
| Regisseur |
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| Producent |
Takashi Shimizu
Hiroyuki Kobayashi Kei Miyamoto |
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| Schrijver |
Joe McClean
Makoto Fukami |
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| Muzikant |
Kenji Kawai
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BSAA Chris Redfield enlists the help of government agent Leon S. Kennedy and Professor Rebecca Chambers from Alexander Institute of Biotechnology to stop a death merchant with a vengeance from spreading a deadly virus in New York. |
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