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| Martin Lawrence | Malcolm / Big Momma | |
| Brandon T. Jackson | Trent / Charmaine | |
| Jessica Lucas | Haley | |
| Michelle Ang | Mia | |
| Portia Doubleday | Jasmine | |
| Emily Rios | Isabelle | |
| Ana Ortiz | Gail | |
| Henri Lubatti | Vlad | |
| Lorenzo Pisoni | Dmitri | |
| Tony Curran | Chirkoff | |
| Marc John Jefferies | Rembrandt | |
| Brandon Gill | Scratch | |
| Zack Mines | Delante | |
| Rhett Lindsey | TJ | |
| Ken Jeong | Mailman | |
| Martin Lawrence | Malcolm | |
| Brandon T. Jackson | Trent | |
| Max Casella | Canetti | |
| Susan Walters | Mall Mother | |
| Sherri Shepherd | Beverly Townsend | |
| Susan Griffiths | Cafeteria Girl #1 | |
| Brianne Gould | Cafeteria Girl #2 | |
| Dawntavia Bullard | Cafeteria Girl - Another Girl | |
| Mari Morrow | Ms. Mercier | |
| Susie Spear Purcell | Art Teacher | |
| Lily Chambers | Drama Queen #1 | |
| Jasmine Burke | Drama Queen #2 |
| Regisseur |
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| Producent |
Arnon Milchan
Michael Green William Paul Clark David T. Friendly |
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| Schrijver |
Don Rhymer
Darryl Quarles Matthew Fogel |
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| Camerawerk |
Anthony B. Richmond
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| Muzikant |
David Newman
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FBI agent Malcolm Turner and his 17-year-old son, Trent, go undercover at an all-girls performing arts school after Trent witnesses a murder. Posing as Big Momma and Charmaine, they must find the murderer before he finds them. |
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