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| Seth Rogen | Mac Radner | |
| Zac Efron | Teddy Sanders | |
| Rose Byrne | Kelly Radner | |
| Chloe Moretz | Shelby | |
| Ike Barinholtz | Jimmy | |
| Kiersey Clemons | Beth | |
| Dave Franco | Pete | |
| Jerrod Carmichael | Garf | |
| Christopher Mintz-Plasse | Scoonie | |
| Beanie Feldstein | Nora | |
| Clara Mamet | Maranda | |
| Awkwafina | Christine | |
| Selena Gomez | Phi Lambda President | |
| Hannibal Buress | Officer Watkins | |
| Elise Vargas | Stella | |
| Zoey Vargas | Stella | |
| Carla Gallo | Paula | |
| John Early | Darren | |
| Johnny Pemberton | Frat President | |
| Kyle Mooney | R.A. | |
| Lisa Kudrow | Dean Carol Gladstone | |
| Ian Gregg | Second Frat Guy | |
| Jacob Wysocki | Live Tinder Guy | |
| Liz Cackowski | Wendy the Realtor | |
| Kelsey Grammer | Shelby's Dad |
| Regisseur |
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| Producent |
Nathan Kahane
Joseph Drake Maria Blasucci Andrew Jay Cohen |
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| Schrijver |
Nicholas Stoller
Seth Rogen Andrew Jay Cohen Brendan O'Brien |
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| Camerawerk |
Brandon Trost
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| Muzikant |
Michael Andrews
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A sorority moves in next door to the home of Mac and Kelly Radner who have a young child. The Radner's enlist their former nemeses from the fraternity to help battle the raucous sisters. |
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