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| Jake Gyllenhaal | Robert Graysmith | |
| Mark Ruffalo | Inspector David Toschi | |
| Anthony Edwards | Inspector William Armstrong | |
| Robert Downey Jr. | Paul Avery | |
| Brian Cox | Melvin Belli | |
| John Carroll Lynch | Arthur Leigh Allen | |
| Richmond Arquette | Zodiac 1 / Zodiac 2 | |
| Bob Stephenson | Zodiac 3 | |
| John Lacy | Zodiac 4 | |
| Chloë Sevigny | Melanie | |
| Ed Setrakian | Al Hyman | |
| John Getz | Templeton Peck | |
| John Terry | Charles Thieriot | |
| Candy Clark | Carol Fisher | |
| Elias Koteas | Sgt. Jack Mulanax | |
| Richmond Arquette | Zodiac 1 | |
| Dermot Mulroney | Captain Marty Lee | |
| Donal Logue | Captain Ken Narlow | |
| June Diane Raphael | Mrs. Toschi | |
| Ciara Moriarty | Darlene Ferrin | |
| Lee Norris | Young Mike Mageau | |
| Patrick Scott Lewis | Bryan Hartnell | |
| Pell James | Cecilia Shepard | |
| Philip Baker Hall | Sherwood Morrill | |
| David Lee Smith | Father | |
| Jason Wiles | Lab Tech Dagitz |
| Regisseur |
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| Producent |
Mike Medavoy
Arnold Messer Cean Chaffin Bradley J. Fischer |
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| Schrijver |
James Vanderbilt
Robert Graysmith |
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| Camerawerk |
Harris Savides
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| Muzikant |
David Shire
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The true story of the investigation of the "Zodiac Killer", a serial killer who terrified the San Francisco Bay Area, taunting police with his ciphers and letters. The case becomes an obsession for three men as their lives and careers are built and destroyed by the endless trail of clues. |
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