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| Ryan Reynolds | Jerry / Mr. Whiskers (voice) / Bosco (voice) / Deer (voice) / Bunny Monkey (voice) | |
| Gemma Arterton | Fiona | |
| Anna Kendrick | Lisa | |
| Jacki Weaver | Dr. Warren | |
| Ella Smith | Alison | |
| Paul Chahidi | Dennis Kowalski | |
| Stanley Townsend | Sheriff Weinbacher | |
| Adi Shankar | John | |
| Sam Spruell | Dave | |
| Valerie Koch | Jerry's Mother | |
| Gulliver McGrath | Jerry (12 years old) | |
| Paul Brightwell | Jerry's Stepfather | |
| Alessa Kordeck | Sheryl | |
| Michael Pink | Jesus | |
| Ricardia Bramley | Sheila Hammer | |
| Ryan Reynolds | Jerry | |
| Alex Tondowski | Tom | |
| Harvey Friedman | Ned TV | |
| Stephanie Vogt | Tina TV | |
| Aaron Kissiov | Jerry (6 Years Old) | |
| Kai Fung Rieck | Chinese Elvis | |
| Antje Rau | Female Cop (Gas Mask) | |
| Cairo | Mr. Whiskers | |
| Hamish | Bosco | |
| Spike | Pighead | |
| Helena Prince | Sierra Club Leader |
| Regisseur |
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| Producent |
Cathy Schulman
Roy Lee Nicole Barton Christoph Fisser |
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| Schrijver |
Michael R. Perry
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| Camerawerk |
Maxime Alexandre
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| Muzikant |
Olivier BERNET
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A mentally unhinged factory worker must decide whether to listen to his talking cat and become a killer, or follow his dog's advice to keep striving for normalcy. |
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