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| Kate Beckinsale | Eliza Graves | |
| Jim Sturgess | Edward Newgate | |
| David Thewlis | Mickey Finn | |
| Brendan Gleeson | The Alienist | |
| Ben Kingsley | Silas Lamb | |
| Michael Caine | Benjamin Salt | |
| Jason Flemyng | Swanwick | |
| Sophie Kennedy Clark | Millie | |
| Sinéad Cusack | Mrs. Pike | |
| Edmund Kingsley | Charles Graves | |
| Robert Hands | Elegant Lady | |
| Ciara Flynn | Farmer's Daughter | |
| Christopher Fulford | Paxton | |
| Andrew Dallmeyer | Jeremiah | |
| Guillaume Delaunay | Arthur Timbs | |
| Krasimir Nedev | Napoleon | |
| Anton Trendafilov | Balzoni | |
| Stefan Shterev | Finn's Goon #1 | |
| Malin Krastev | Finn's Goon #2 | |
| Yordan Zahariev | Farmer | |
| Gabrielle Downey | Blind Women | |
| Dejan Angelov | Filthy Man | |
| Petya Kamenova | Maid | |
| Petya Dimanova | Nun | |
| Marta Gutiérrez-Abad | Nurse |
| Regisseur |
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| Producent |
Bruce Davey
Mel Gibson Mark Amin René Besson |
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| Schrijver |
Joe Gangemi
Edgar Allan Poe |
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| Camerawerk |
Thomas Yatsko
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| Muzikant |
John Debney
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A Harvard Medical School graduate takes a position at a mental institution and soon becomes obsessed with a female mental patient, but he has no idea of a recent and horrifying staffing change. |
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