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| Robert Downey Jr. | Sherlock Holmes | |
| Jude Law | Dr. John Watson | |
| Noomi Rapace | Madam Simza Heron | |
| Rachel McAdams | Irene Adler | |
| Jared Harris | Professor James Moriarty | |
| Stephen Fry | Mycroft Holmes | |
| Paul Anderson | Colonel Sebastian Moran | |
| Kelly Reilly | Mary Watson | |
| Geraldine James | Mrs. Hudson | |
| Eddie Marsan | Inspector Lestrade | |
| William Houston | Constable Clark | |
| Wolf Kahler | Doctor Hoffmanstahl | |
| Iain Mitchell | Auctioneer | |
| Jack Laskey | Carruthers | |
| Patricia Slater | Shush Club Maitre D' | |
| Karima McAdams | Shush Club Maitre D' | |
| Richard Cunningham | Businessman | |
| Marcus Shakesheff | Hashisheen | |
| Mark Sheals | Cock Fight Referee | |
| George Taylor | University Student | |
| Michael Webber | Vicar | |
| Mike Grady | Train Conductor | |
| Alexandre Carril | Twin | |
| Victor Carril | Twin | |
| Thorston Manderlay | Alfred Meinhard |
| Regisseur |
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| Producent |
Bruce Berman
Joel Silver Steve Clark-Hall |
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| Schrijver |
Arthur Conan Doyle
Michele Mulroney Kieran Mulroney |
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| Camerawerk |
Philippe Rousselot
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| Muzikant |
Hans Zimmer
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There is a new criminal mastermind at large (Professor Moriarty) and not only is he Holmes’ intellectual equal, but his capacity for evil and lack of conscience may give him an advantage over the detective. |
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Materiaal
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