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| Dwayne Johnson | Hank | |
| Michael Caine | Alexander | |
| Josh Hutcherson | Sean | |
| Luis Guzman | Gabato | |
| Vanessa Anne Hudgens | Kailani | |
| Kristin Davis | Liz | |
| Anna Colwell | Jessica | |
| Stephen Caudill | Cop | |
| Branscombe Richmond | Tour Guide | |
| Walter Bankson | Hockey Player | |
| Cody Easterbrook | Palauan | |
| Kathryn Jurbala | Tourist | |
| Paul Leo Klink | Nautilus Passenger | |
| Ed Moy | Fisherman | |
| Darwin Reina | Tourist |
| Regisseur |
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| Producent |
Beau Flynn
Michael Bostick Richard Brener |
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| Schrijver |
Jules Verne
Brian Gunn Mark Gunn |
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| Camerawerk |
David Tattersall
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| Muzikant |
Andrew Lockington
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Sean Anderson partners with his mom's boyfriend on a mission to find his grandfather, who is thought to be missing on a mythical island. |
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